Low Blood Statis – Ge Xia Zhu Yu Pian Extra Strong (Drive Out Blood Stasis Below the Diaphragm Decoction) 120 tablet 10:1 500mg

Nonalcoholic Fatty Liver Disease (NAFLD):
Animal studies demonstrate that GXZY improves lipid metabolism (increases HDL, decreases LDL and total cholesterol), reduces hepatic fat accumulation, and alleviates inflammation and fibrosis. It acts by altering miRNA-24 expression and regulating TRPM4, contributing to lipid-lowering, anti-inflammatory, and antioxidant effects1.
Key compounds, such as hydroxysafflor yellow A, paeoniflorin, and ferulic acid, are linked to antifibrotic and antioxidant properties.

Liver Cirrhosis and Fibrosis:
Network pharmacology and animal experiments show GXZY targets genes and pathways (AR, JUN, MYC, CASP3, MMP9, GAPDH, RELA) involved in inflammation, apoptosis, and fibrosis. It inhibits hepatic stellate cell proliferation, reduces liver injury and collagen deposition, and downregulates MMP9 expression3.
GXZY induces apoptosis of hepatic stellate cells via increased caspase 3 and 12 expression, contributing to the resolution of fibrosis.

Pain, Masses, and Gynecological Disorders
Abdominal Pain and Masses:
GXZY is indicated for fixed, localized abdominal pain, palpable masses, and heaviness below the diaphragm due to blood stasis and qi stagnation. Clinical reports support its use for chronic hepatitis, cirrhosis, and abdominal pain associated with blood stasis6.
Gynecological Applications:
Used for chronic pelvic inflammatory disease, endometriosis, dysmenorrhea, and menstrual irregularities. GXZY improves pelvic circulation, relieves pain, and may support fertility in blood stasis-related cases6.